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Methicillin-resistant Staphylococcus aureus (MRSA) neutropenic thigh infection model

Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen that is currently accounts for the majority of skin and soft tissue infections (SSTIs) in the United States. As mice are less susceptible to S. aureus infection they are first made neutropenic.

The neutropenic thigh infection model is an ideal PK/PD model for the assessment of the efficacy of novel antibiotics and antimicrobials. In this model there is tissue burden for a minimum of 24 hours which is significantly reduced by subcutaneously administered Vancomycin.

Results from 6, 12, and 24 hours
Study Design

CD-1 mouse

Model Methicillin-resistant Staphylococcus aureus (MRSA) neutropenic thigh infection model
Relevant Use Efficacy of novel antibiotics and antimicrobials
Readouts Available Daily Bodyweights and Clinical Signs, Bacterial load, systemic cytokines and Pathology

Study data generated by Labcorp Huntingdon Pharmacology.